Dipartimento di Scienza e Tecnologia del Farmaco

Descrizione del progetto

Members of other units:
Dr. N. Birocco
Dr. F. Cattel

Prof. L. Cattel
Dr. L. Ciuffreda
Dr. M. Schena
S. Storto

Partners:
Medical Oncology 1, San Giovanni Battista Hospital, Turin, Italy
Hospital Pharmacy, San Giovanni Battista Hospital, Turin, Italy
S.C.D.U. - Psicologia Clinica e Oncologica, Dept. di Neuroscienze e Oncologia, University of Turin, Italy

Sponsors:
Dr. L. Ciuffreda, Medical Oncology 1, San Giovanni Battista Hospital, Turin, Italy

Description:

This study, which full title is “Approccio al counseling dei pazienti oncologici sottoposti a terapia orale: apporto del gruppo multidisciplinare medico-infermiere-farmacista-psiconcologo”, started in 2010. It’s an observational randomized open clinical trial.

Recently many oncologic medicinal products for oral administration have been introduced. Oral administration shows many advantages respect to the iv one, as improvement of life style, reduction of venous infections and reduction of health spending, concerning above all medical devices and health assistance. For the medical doctor the problem, on the contrary, is the poor check on the adherence to the therapy by his patients.

The aim of this study is the evaluation of the efficacy of the counseling managed with a multitask group formed by medical doctor-nurse-pharmacist-pshyconcologist: it is studied the improvement of adherence to the oral therapy of oncologic patients respect to those which received the counseling from medical doctor-nurse only. Erlotinib, Sorafenib o Sunitinib have been chosen as API to select the patients to enroll. Some initial questionnaires have been administrated to the enrolled subjects at the beginning of the trial, moreover, during the routinely hospital check previewed by therapeutic protocol, the evaluation of steady state plasmatic level of the administered API has been ascertain by HPLC analysis.

At the end of 2014, all the collected data are analyzed in order to obtain the conclusions of the study.

Keywords:

Chemos, HPLC, psycho-oncology, oncological patients, anticancer drugs, clinical trial.