Vai al contenuto principale

Emulsions as vehicle to reduce the side effects of different drugs in animal and man (High-Toler_Emu)

Docente

Paola Milla

Aree / Gruppi di ricerca

Partecipanti al progetto

Descrizione del progetto

Members of other units:
Paolo Romano, Tiberio Bruzzese (Bixio Consulting)

Sponsors:
Local funds (ex_60%) University of Turin, Italy 
Funds from Bixio Consulting, Milan, Italy 

Description
Emulsion formulations using both commercial available products (Lipofundin, Intralipid) or customized formulations, contribute to the reduction of side effects of several potent drugs injected i.m or i.v. In particular injection of clodronic acid is  painful causing discomfort in several patients. With lipids or phospholipids emulsion formulation the dolorability of high concentration of clodronic acid assayed in rat is totally resolved. Novel emulsion formulations of high concentration of hydrophilic drugs demonstrated to protect the tissues of animals without interfering with pharmacokinetics.  This approach is now ongoing in different fields and administration routes.

References:
- Ghi P. et al , 2013. J. Pharm. Pharmacol.  in press
- Bruzzese T. 2012 US2012322767
- Bruzzese T. 20005 WO2005044280

Keywords:
Emulsion, Bisphosphonate, Tolerability, Clodronate, Zoledronate, Pamidronate, Alendronate

Ultimo aggiornamento: 14/10/2022 09:53
Non cliccare qui!