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Anticancer drugs-loading into new mesoporous silica nanoparticles (Anti Cancer Drugs New-MSN-)

Docente
Dott. Barbara STELLA
Coordinatore/trice
Prof. Silvia ARPICCO

Aree / Gruppi di ricerca

Partecipanti al progetto

Descrizione del progetto

Membri:
Gloria Berlier   (Dip. di Chimica)

Members of other units:

Alessio Malfanti
Lucia Scolaro

Sponsors:
Local funds (ex60%) University of Turin, Italy

Description
This project is based on the preparation and characterization of mesoporous silica nanoparticles (MSN) loaded with different anticancer (pyrimidine analogues) drugs and their corresponding prodrugs. The prodrugs contain fatty acids tails in order to increase their lipophilicity and thus their loading efficiency. The nanoparticles are fully characterized from a technological point of view and their cytotoxic activity is evaluated in vitro in different human cancer cell lines.

References:
- Arpicco S. et al, 2011. Current topics in medicinal chemistry 11, 2346-2381
- Berlier G. et al, 2013. Journal of Colloid and Interface Science 393, 109–118

Keywords:
Anticancer agents, Nanoparticles, Pyrimidine analogues, Mesoporous Silica Nanoparticles, Prodrugs

Ultimo aggiornamento: 30/03/2015 15:51
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