"Pharmacology of Autacoids (PHARMACOIDS)"
Our research focuses on the identification, characterisation and validation of novel targets for the treatment of acute and chronic renal dysfunction. In particular, we are interested in the histaminergic system and we are currently mapping the histamine receptor subtypes expression and assessing their functional role in the kidney, already providing the first evidence for the presence of the histamine H4 receptor in the kidney of diabetic rats. Our approach to research is a close in vitro, ex vivo and in vivo integration by using both human renal cell lines and primary renal cells isolated from humans, mice and rats, biochemical analysis on both cells and tissues, immunoistochemical analysis of tissue specimens, in vivo model of diabetes-induced renal dysfunction.
Autacoids, Histaminergic system, Histamine receptors, Kidney