Encapsulation of antitumoral drugs and curcumin as Pgp inhibitor in solid lipid nanoparticles (SLN)
Aree / Gruppi di ricerca
- * Pharmaceutical Technologies
- Group Innovative Pharmaceutical and Cosmetic Technology and Nanotechnology Group (i-PHARCOTEC)
Partecipanti al progetto
- Peira Elena (Coordinatore/trice)
- Chirio Daniela (Ricercatore/trice)
- Gallarate Marina (Docente)
- Sapino Simona (Tecnico/a)
Descrizione del progetto
Members:
Prof.ssa RIGANTI Chiara, Dipartimento di Oncologia
Description:
Multidrug resistance is a phenomenon associated with decreased intracellular drug accumulation in the tumor cells due to drug efflux, often related to the overexpression of P-glycoprotein (Pgp) on the surface of tumor cells and motive of failure cancer therapy.
The aim of project is the development of SLN and chitosan-coated SLN able to encapsulate curcumin in order to associate these to other antitumoral drugs such as paclitaxel, floxuridine, etoposide, doxorubicin and to decrease the multidrug resistance.
SLN will be prepared using the innovative method called "cold dilution of microemulsion” and characterized by DLS, SEM, DSC analyses and drug encapsulation efficiency will be determined.
Curcumin-loaded SLN, alone and in association with antitumoral drugs (free or loaded into SLN), will be tested in vitro on different tumor cell lines for its potential ability to modulate the expression and function of Pgp.