The study of the effect of post-squalene deficiencies and cholesterol intermediates accumulation (mainly those dependent on malfunctioning of C-4 demethylation complex) on (i) other enzymes of post-squalene cholesterol biosynthesis, (ii) the mammalian embryo development and (iii) the Hedgehog protein-dependent tumors.
This study will be achieved by:
The study of the antiangiogenic and antitumoral activity of the sterol biosynthesis inhibitors and biochemical mechanism involved.
Techniques and facilities:
- Matti Poutanen, Turku Center for Disease Modelling, Turku, Finland.
- Gail Herman, Herman Lab. Center for Human and Molecular Genetics, the Research Institute at Nationwide Children's Hospital, Columbus).
- Donald Poirier, Department of Molecular Medicine, Research Center and Laval University, Quebec City, Canada.
- Martin Bard, IUPU University, Indianapolis, USA
Cholesterol, Cholesterol biosynthesis, Inhibitors, C-4 sterol demethylase, Postsqualene sterol biosynthesis, Antitumoral activity, Antiangiogenic activity, Enzymatic activity, Cholesterol disorders, Hedgehog proteins, Cell proliferation, Signalling pathway
Turku Center for Disease Modelling