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Encapsulation of antitumoral drugs and curcumin as Pgp inhibitor in solid lipid nanoparticles (SLN)

Periodo
Dal 02/01/2017
Docente
Prof. Marina GALLARATE
Coordinatore/trice
Dott. Elena PEIRA

Aree / Gruppi di ricerca

Partecipanti al progetto

Descrizione del progetto

Members:

Prof.ssa RIGANTI Chiara, Dipartimento di Oncologia

Description:

Multidrug resistance is a phenomenon associated with decreased intracellular drug accumulation in the tumor cells due to drug efflux, often related to the overexpression of P-glycoprotein (Pgp) on the surface of tumor cells and motive of failure cancer therapy.

The aim of project is the development of SLN and chitosan-coated SLN able to encapsulate curcumin in order to associate these to other antitumoral drugs such as paclitaxel, floxuridine, etoposide, doxorubicin and to decrease the multidrug resistance.

SLN will be prepared using the innovative method called "cold dilution of microemulsion” and characterized by DLS, SEM, DSC analyses and drug encapsulation efficiency will be determined.

Curcumin-loaded SLN, alone and in association with antitumoral drugs (free or loaded into SLN), will be tested in vitro on different tumor cell lines for its potential ability to modulate the expression and function of Pgp.

 

Ultimo aggiornamento: 30/06/2017 15:25
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