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"Innovative Pharmaceutical and Cosmetic Technology and Nanotechnology Group (i-PHARCOTEC)"

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Description:

Research activities in progress in pharmaceutical field:

  • Preparation of conventional and innovative drug formulations;
  • Formulation and characterization of micro-nanoparticles (lipid, polymeric and inorganic) for drug delivery (Figure 1);
  • Development of innovative technologies for lipid and polymeric nanoparticles;
  • Characterization of solid and liquid (i.e. nano- and microemulsions) colloidal systems;
  • Design of dermal and transdermal systems
  • Pharmaceutical technical procedures
  • Technological strategy to improve drug solubility/stability/release (i.e. cyclodextrins, nanocrystals)
  • Nanovescicle systems (i.e. nanobubbles and nanocapsules)
  • Non-viral strategy for gene delivery


Research activities in progress in cosmetic field:

  • Formulation and characterization of solid, semi-solid and liquid colloidal systems for topical application.
  • Development of host-guest complexes with supramolecular structures (i.e. mesoporous silica-Figure 2) to improve the stability and the effectiveness of entrapped compound, and to modulate the release over time and the skin uptake.
  • Interesting molecules in dermatological and cosmetic fields: natural antioxidants; vitamins; organic and inorganic UV-filters; photosensitizers; other drugs for skin disorders.

Main available technologies:

  • Freeze drying
  • Thermal analysis (DSC)
  • Particle size and Zeta potential determination (DLS)
  • Multi Flow FFF Separation
  • Optical microscopy
  • Rheology measurements
  • In vitro permeation studies (synthetic membranes/skin slice/corneas) with Franz cells
  • Photostability studies (sunlight simulators, Figure 3)
  • Stability studies of disperse systems
  • Conductivity and surface tension evaluation
  • Non-invasive determination of physiological skin parameters (corneometer+sebumeter+ skin pH-meter, Figure 4).

upload_pharcotec_fig.1.jpgFigure 1. Solid lipid nanoparticles

 

 

upload_pharcotec_fig.2.jpg

Figure 2. Host-guest complexes with mesoporous silica

upload_pharcotec_fig.3.jpgFigure 3. Sunlight simulator

upload_pharcotec_fig.4.jpgFigure 4. Corneometer+sebumeter+skin pH-meter

Keywords:
Solid lipid nanoparticles, Nano and microemulsions, Colloidal delivery systems, Photostability, Antioxidants, Mesoporous silica nanoparticles, Dermocosmetic formulations, Titanium dioxide, Nanobubbles, Nanocapsules, Cyclodextrins

Ultimo aggiornamento: 03/11/2016 13:54
Campusnet Unito
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