"Bimodal Treatments Research (BMT)"
Bimodal therapies aim to exploit synergistic effects arising from two components of either chemical or physical nature, in the same region of space, with the final goal of maximizing the therapeutic efficacy. In particular, our group is investigating on anticancer photodynamic therapy (PDT) and sonodynamic therapy (SDT) that are based on the preferential uptake and/or retention of a sensitizer in tissues and its subsequent activation by light or ultrasound, respectively. Our primary aim is to study the in vitro and in vivo anticancer efficacy of SDT highlighting its underpinning mechanism of action and developing new sonosensitizers. As the proposed research is truly interdisciplinary in its nature, it is designed to rely on face-to-face work and sharing expertise in chemistry, physics, biology and medicine with the ultimate goal to exploit nanotechnology to boost these external stimuli-based anticancer approaches.
Keywords: Bimodal therapies, Photodynamic therapy, Sonodynamic therapy, Light, Ultrasound, Shock Waves, Porphyrins, Cavitation, Sonoluminescence, Nanoparticles, Spheroids