Dipartimento di Scienza e Tecnologia del Farmaco

Department of Medical Sciences, University of Turin 

Department of Pharmacological and Biomolecular Sciences, University of Milan

Selected Publications
1. Massimo Bertinaria, Giovanni Sorba, Claudio Medana, Clara Cena, Maristella Adami, Giuseppina Morini, Cristina Pozzoli, Gabriella Coruzzi, and Alberto Gasco; “Synthesis and Pharmacological Characterization of New H2-Antagonists Conatining NO-Donor Moieties, Endowed with Mixed Antisecretory and Gastroprotective Activities”, Helv. Chimica Acta 2000, 83, 287-299.

2. Massimo Bertinaria, Antonella Di Stilo, Paolo Tosco, Giovanni Sorba, Enzo Poli Cristina Pozzoli, Gabriella Coruzzi, Roberta Fruttero, Alberto Gasco; “[3-(1H-Imidazol-4-yl)propyl]guanidines Containing Furoxan Moieties: A new Class of H3-antagonists Endowed with NO-Donor Properties”; Bioorg. Med. Chem. 2003, 11, 1197-1205.
3. Donatella Boschi, Gian Cesare Tron, Loretta Lazzarato, Konstantin Chegaev, Clara Cena, Antonella Di Stilo, Marta Giorgis, Massimo Bertinaria, Roberta Fruttero and Alberto Gasco; “NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties”; J. Med. Chem. 2006, 49, 2886-2897.

4. M. Federica Buonsanti, Massimo Bertinaria, Antonella Di Stilo, Clara Cena, Roberta Fruttero and Alberto Gasco; ”Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans”; J. Med. Chem. 2007, 50, 5003-5011.

5. Stefano Guglielmo, Massimo Bertinaria, Barbara Rolando, Marco Crosetti, Roberta Fruttero, Vanessa Yardley, Simon L. Croft, Alberto Gasco.; “A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity” Eur. J. Med. Chem. 2009, 44, 5701-5709.

6. Massimo Bertinaria, Barbara Rolando, Marta Giorgis, Gabriele Montanaro, Stefano Guglielmo, M. Federica Buonsanti, Valentina Carabelli, Daniela Gavello, Pier Giuseppe Daniele, Roberta Fruttero, Alberto Gasco.; “Synthesis, Physicochemical Characterization, and Biological Activities of New Carnosine Derivatives Stable in Human Serum As Potential Neuroprotective Agents” J. Med. Chem. 2011, 54, 611-621.

7. Massimo Bertinaria, Stefano Guglielmo, Barbara Rolando, Marta Giorgis, Cristina Aragno, Roberta Fruttero, Alberto Gasco, Silvia Parapini, Donatella Taramelli, Yuri C. Martins, Leonardo J.M. Carvalho; “Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria” Eur. J. Med. Chem. 2011, 46, 1757-1767.

8. Massimo Bertinaria, Barbara Rolando, Marta Giorgis, Gabriele Montanaro, Elisabetta Marini, Massimo Collino, Elisa Benetti, Pier Giuseppe Daniele, Roberta Fruttero, Alberto Gasco.; “Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile” Eur. J. Med. Chem. 2012, 54, 103-112

9. Massimo Bertinaria, Mohammed Abrar Abdul Gaffar Shaikh, Carola Buccellati, Clara Cena, Barbara Rolando, Loretta Lazzarato, Roberta Fruttero, Alberto Gasco, Malvina Hoxha, Valérie Capra, Angelo Sala, G. Enrico Rovati; “Designing multitarget anti-inflammatory agents: chemical modulation of lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors”, ChemMedChem 2012, 7, 1647-1660.

10. Gabriele Montanaro, Massimo Bertinaria, Barbara Rolando, Roberta Fruttero, Christopher D. Lucas, David A. Dorward, Adriano G. Rossi, Ian L. Megson, Alberto Gasco, “Novel R-Roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents”, Bioorg. Med. Chem. 2013, 21, 2107-2116

Different multitarget approaches to manage coxibs associated cardiovascular risk.
Design and synthesis of new lumiracoxib derivatives

21 National meeting on medicinal chemistry, Palermo 17-20 July 2012

Discovery of small molecules acting on NLRP3 inflammasome and related pathways

Discovery of new DNA methyltransferases modulators