NOPhArm (DRUG DESIGN- NO Prodrugs and hybrids)
Componenti
- Fruttero Prof. Roberta (Coordinatore/Coordinatrice)
- Blangetti Dott. Marco (Borsista)
- Chegaev Prof. Konstantin (Docente)
- Guglielmo Prof. Stefano (Docente)
- Lazzarato Prof. Loretta (Docente)
- Rolando Prof. Barbara (Docente)
- Sodano Dott. Federica (Dottorando/a)
- Spyrakis Prof. Francesca (Docente)
Contatti
Attività
The NO-PhArm group has developed a solid expertise in multi-target drugs. The ability to bind and modulate multiple biological targets within a single molecule offers several distinct advantages compared to combination therapies, most importantly consistent and predictable pharmacokinetics.
Our research is principally focused on:
- NO-donor Aspirin-like molecules
- NO-donor multi-target drugs obtained by joining selected NO-donor moieties with a variety of appropriate pharmacophores
- Development of novel furoxan, nitric ester, nitrosothiol, diazeniumdiolate NO-donors
Other topics:
- Design of molecules aimed at reverting multi-drug resistance (MDR)
- H2S-donor multi-target drugs
Our labs feature a comprehensive research pipeline, including:
- design
- synthesis
- analytical, physicochemical and structural characterization
- in silico and in vitro screening
Facilities
- Fully equipped organic synthesis labs
- Wide array of analytical instrumentation including multiple HPLC chromatographs (analytical, semi-preparative and preparative), NO-sensitive electrodes, chemiluminescence, Sirius GlpKa microtitration apparatus
- In-house access to main spectroscopic techniques for structural characterization and purity assessment (NMR, MS/LC-MS, FT-IR, UV)
- Instrumentation for in vitro biochemical and pharmacological assays (e.g., antiaggregatory, antioxidant, COX/LOX inhibitory activity)
- Nicox Research (Sophie Antipolis, France)
- Laboratoire de Chimie Thérapeutique - Pharmacochimie (Université de Genève, Switzerland)
- Institute des Sciences Moléculaires de Marseille (Université Aix-Marseille, France)
- La Jolla Bioengineering Institute, (San Diego, California, USA)
- Department of Immunology/Microbiology (Rush University Medical Center, Chicago, Illinois, USA)
- Department of Oncology - School of Medicine (University of Turin, Italy)
- MRC Centre for Inflammation Research (University of Edinburgh, UK)
- Department of Diabetes and Cardiovascular Science (University of the Highlands and Islands, UK)
- Alberto Gasco, Professor in Medicinal Chemistry
